Journal of the American Society of Hypertension
Volume 6, Issue 1 , Pages 23-26 , January 2012

Neural regulation of the immune system modulates hypertension-induced target-organ damage

  • Friedrich C. Luft, MD

      Affiliations

    • Corresponding Author InformationCorresponding author: Friedrich C. Luft, MD, Lindenbergerweg 80, 13125 Berlin, Germany.

Received 28 September 2011 ,Accepted 28 September 2011.

References 

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  2. Rodríguez-Iturbe B, Quiroz Y, Nava M, Bonet L, Chávez M, Herrera-Acosta J, et al. Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats. Am J Physiol Renal Physiol. 2002;282:F191–F201
  3. Muller DN, Shagdarsuren E, Park JK, Dechend R, Mervaala E, Hampich F, et al. Immunosuppressive treatment protects against angiotensin II-induced renal damage. Am J Pathol. 2002;16:1679–1693
  4. Guzik TJ, Hoch NE, Brown KA, McCann LA, Rahman A, Dikalov S, et al. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med. 2007;204:2449–2460
  5. Gratze P, Dechend R, Stocker C, Park JK, Feldt S, Shagdarsuren E, et al. Novel role for inhibitor of differentiation 2 in the genesis of angiotensin II-induced hypertension. Circulation. 2008;117:2645–2656
  6. Marvar PJ, Thabet SR, Guzik TJ, Lob HE, McCann LA, Weyand C, et al. Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II-induced hypertension. Circ Res. 2010;107:263–270
  7. Brody MJ. Central nervous system and mechanisms of hypertension. Clin Physiol Biochem. 1988;6:230–239
  8. Fisher JP, Paton JF. The sympathetic nervous system and blood pressure in humans: implications for hypertension. J Hum Hypertens. 2011;10:[Epub ahead of print]
  9. Tracey KJ. Reflex control of immunity. Nat Rev Immunol. 2009;9:418–428
  10. Rosas-Ballina M, Olofsson PS, Ochani M, Valdés-Ferrer SI, Levine YA, Reardon C, et al. Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science. 2011 Sep 15;[Epub ahead of print]
  11. Sun J, Sign V, Kajino-Sakamoto R, Aballay A. Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes. Science. 2011;332:729–732
  12. Zhang Y, Popovic ZB, Bibevski S, Fakhry I, Sica DA, Van Wagoner DR, et al. Chronic vagus nerve stimulation improves autonomic control and attenuates systemic inflammation and heart failure progression in a canine high-rate pacing model. Circ Heart Fail. 2009;2:692–699
  13. Tank J, Jordan J, Diedrich A, Obst M, Plehm R, Luft FC, et al. Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation. Hypertension. 2004;43:1042–1047

PII: S1933-1711(11)00242-7

doi: 10.1016/j.jash.2011.09.006

Journal of the American Society of Hypertension
Volume 6, Issue 1 , Pages 23-26 , January 2012

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