Journal of the American Society of Hypertension
Volume 4, Issue 5 , Pages 211-214, September 2010

Central blood pressure measurements—an opportunity for efficacy and safety in drug development?

  • Raymond R. Townsend, MD

      Affiliations

    • University of Pennsylvania, Philadelphia, Pennsylvania, USA
    • Corresponding Author InformationCorresponding author: Raymond R. Townsend, MD, University of Pennsylvania, 122 Founders Building, 3400 Spruce Street, Philadelphia, Pennsylvania 19104. Tel: 215–662–4630; fax: 215–662–3459.
    • ,
  • Mary J. Roman, MD

      Affiliations

    • Weill Cornell Medical College, New York, New York, USA
    • ,
  • Samer S. Najjar, MD

      Affiliations

    • Washington Hospital Center, Washington, DC, USA
    • ,
  • John R. Cockcroft, MD

      Affiliations

    • Wales Heart Institute, Cardiff, Wales, UK
    • ,
  • Peter U. Feig, MD

      Affiliations

    • Merck & Co., Rahway, New Jersey, USA
    • ,
  • Norman L. Stockbridge, MD, PhD

      Affiliations

    • Food and Drug Administration, Rockville, Maryland, USA

published online 23 August 2010.

Abstract 

Over a century of experience with brachial blood pressure has produced a substantial amount of information on the role of blood pressure as a factor in heart disease, stroke and kidney failure. Successful interventions lowering blood pressure and reducing damage to vital organs testify further to the importance of this vital sign. In recent years attempts to probe deeper into the value of knowledge of blood pressure levels closer to the heart (central blood pressures) suggest that noninvasive measurement of central aortic blood pressure may improve further efforts directed at both understanding drug benefit and uncovering potential drug safety issues. This commentary is a summary of a one-day meeting with the FDA in which the role of central blood pressure measurements as an adjunct to drug efficacy and safety were addressed.

Keywords: Blood pressure, central blood pressure, pharmacology, drug safety

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PII: S1933-1711(10)00159-2

doi:10.1016/j.jash.2010.07.002

Journal of the American Society of Hypertension
Volume 4, Issue 5 , Pages 211-214, September 2010

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