Journal of the American Society of Hypertension
Volume 3, Issue 5 , Pages 295-305, September 2009

Potentiation of vascular oxidative stress and nitric oxide-mediated endothelial dysfunction by high-fat diet in a mouse model of estrogen deficiency and hyperandrogenemia

  • Danesh Javeshghani, PhD

      Affiliations

    • Vascular and Hypertension Research Unit, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    • Reproduction Research Laboratory, Clinical Research Institute of Montreal, Montreal, University of Montreal, Quebec, Canada
    • Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Ernesto L. Schiffrin, MD, PhD

      Affiliations

    • Vascular and Hypertension Research Unit, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    • ,
  • M. Ram Sairam, PhD

      Affiliations

    • Reproduction Research Laboratory, Clinical Research Institute of Montreal, Montreal, University of Montreal, Quebec, Canada
    • ,
  • Rhian M. Touyz, MD, PhD

      Affiliations

    • Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    • Corresponding Author InformationCorresponding author: Rhian M. Touyz, MD, PhD, Kidney Research Centre, OHRI/University of Ottawa, 451 Smyth Road, Room 1333A, Ottawa, ON K1H 8M5, Canada. Tel: 613-562-5800 (ext. 8241); fax: 613-562-5487.

Received 28 April 2009; accepted 29 July 2009.

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 This study was supported by Grants Nos. 44018 (Dr. Touyz) and 13570 (Dr. Schiffrin) from the Canadian Institutes of Health Research. Drs. Touyz and Schiffrin are supported through Canada Research Chair/Canadian Foundation for Innovation awards. Dr. Javeshghani is the recipient of a Fellowship from the Heart and Stroke Foundation of Canada.

PII: S1933-1711(09)00100-4

doi:10.1016/j.jash.2009.07.002

Journal of the American Society of Hypertension
Volume 3, Issue 5 , Pages 295-305, September 2009

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