« Previous
Next »
Journal of the American Society of Hypertension
Volume 3, Issue 4
, Pages 238-244
, July 2009
A HMGCR polymorphism is associated with relations between blood pressure and urinary sodium and potassium ratio in the Epic-Norfolk Study
References
- . Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217–223
- . Lipid lowering: another method of reducing blood pressure?. J Hum Hypertens. 2002;16:753–760
- Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143–3342
- . ScrFI polymorphism in the 2nd intron of the HMGCR gene [abstract]. Nucleic Acids Res. 1990;18:5584
- . HgiAI polymorphism near the HMGCR promoter [abstract]. Nucleic Acids Res. 1990;18:5584
- . A high frequency of length polymorphism in repeated sequences adjacent to Alu sequences. Am J Hum Genet. 2008;46:963–969
- . Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA. 2004;291:2821–2827
- . Angiotensin AT1 receptor over-expression in hypercholesterolaemia. Ann Med. 2000;32:386–389
- . 3-Hydroxy-3-Methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA. Circulation Res. 2002;91:143–150
- Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2001;21:1896–1901
- . (TTA)n repeat polymorphism in the HMG-CoA reductase gene and cholesterolaemia. VASA. 1999;28:169–171
- . Relationship of genetic variation in genes encoding apolipoprotein A-IV, scavenger receptor BI, HMG-CoA reductase, CETP, and apolipoprotein E with cholesterol metabolism and the response to plant stanol ester consumption. Eur J Clin Invest. 2002;32:242–250
- 8302A/C and (TTA)n polymorphisms in the HMG-CoA reductase gene may be associated with some plasma lipid metabolic phenotypes in patients with coronary heart disease. Lipids. 2004;39:239–241
- . Mechanisms of acute natriuresis in normal humans on low sodium diet. J Physiol. 2003;546:591–603
- . Determinants of the natriuresis after acute, slow sodium loading in conscious dogs. Am J Physiol Regul Integr Comp Physiol. 2000;278:R1–R10
- . Hormonal regulation of renal sodium and water excretion during normotensive sodium loading in conscious dogs. Am J Physiol Regul Integr Comp Physiol. 2000;278:R11–R18
- . Effects of sodium restriction on blood pressure, renin, aldosterone, catecholamines, cholesterols, and triglycerides. JAMA. 1998;279:1383–1391
- . Enhanced blood pressure response to mild sodium reduction in subjects with the 235T variant of the angiotensinogen gene. Am J Hypertens. 1999;12:460–466
- . Blood pressure is linked to salt intake and modulated by the angiotensinogen gene in normotensive and hypertensive elderly subjects. J Hypertens. 2001;19:1053–1060
- Blood pressure and interactions between the angiotensin polymorphism AGT M235T and sodium intake: a cross-sectional population study. Am J Clin Nutr. 2008;88:392–397
- Blood pressure and urinary sodium in men and women: the Norfolk Cohort of the European Prospective Investigation into Cancer (EPIC—Norfolk). Am J Clin Nutr. 2004;80:1397–1403
- Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Public Health Nutr. 2003;6:407–413
- Single-nucleotide polymorphism analysis by pyrosequencing. Anal Biochem. 2000;280:103–110
- . Detection of single-base changes using a bioluminometric primer extension assay. Anal Biochem. 1997;244:367–373
- . Real-time DNA sequencing using detection of pyrophosphate release. Anal Biochem. 1996;242:84–89
- . Stroke prevention, blood cholesterol, and statins. Lancet Neurol. 2004;3:271–278
- . Non-lipid-related effects of statins. Ann Med. 2000;32:164–176
- Effect of the HMG-CoA Reductase inhibitors on blood pressure in patients with essential hypertension and primary hypercholesterolemia. Hypertension. 1999;34:1281–1286
- . Reduction in blood pressure with statins: results from the UCSD Statin Study, a randomized trial. Arch Intern Med. 2008;168:721–727
- . Statins and stroke prevention. Cerebrovasc Dis. 2007;24:170–182
- . The sexual dimorphism of high blood pressure. Cardiol Rev. 1998;6:356–363
- . Sex and the cardiovascular system: the intriguing tale of how women and men regulate cardiovascular function differently. Adv Physiol Educ. 2007;31:17–22
- . Molecular and cellular basis of cardiovascular gender differences. Science. 2005;308:1583–1587
- Validation of dietary assessment methods in the United Kingdom arm of EPIC using weighed records, and 24-hour urinary nitrogen and potassium and serum vitamin C and carotenoids as biomarkers. Int J Epidemiol. 1997;26:S137–S151
- . Statin therapy and prevention of stroke. Curr Atheroscler Rep. 2000;2:181–182
- . Pharmacogenetics of multigenic disease: Heart disease as an example. Vascular Pharmacology. 2006;44:66–74
- Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER. Atherosclerosis. 2008;200:109–114
- . Pharmacogenomics and pharmacogenetics of cholesterol-lowering therapy. Clin Chem Lab Med. 2003;41:581–589
- Genetic analysis of fluvastatin response and dyslipidemia in renal transplant recipients. J Lipid Res. 2007;48:2072–2078
- . Gender-related differences in cardiomyopathy. Cardiovasc Clin. 1989;19:285–300
- . Gender issues in the epidemiology of cardiovascular diseases. Ther Umsch. 2007;64:297–304
- . Cardiovascular alteration and treatment of hypertension: do men and women differ?. Endocrine. 2005;28:199–207
- . Gender aspects of the role of the metabolic syndrome as a risk factor for cardiovascular disease. Gend Med. 2007;4:S162–S177
- . Controlled analysis of blood pressure sensitivity to sodium intake: interactions with hypertension type. J Hypertens. 2003;21:951–959
- . Abnormal renal sodium handling in essential hypertension. Relation to failure of renal and adrenal modulation of responses to angiotensin II. Am J Med. 1986;81:412–418
- . Heritable aspects of salt sensitivity. Am J Cardiol. 1988;61:1H–6
- Mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac GTPase. Mol Pharmacol. 2001;59:646–654
- HMG-CoA reductase inhibitors decrease angiotensin II-induced vascular fibrosis: role of RhoA/ROCK and MAPK pathways. Hypertension. 2007;50:377–383
This study was supported by Programme Grants from the Medical Research Council, London, United Kingdom; Cancer Research, London, United Kingdom; and Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq, Brazil (a fellowship to Dr. Freitas).
Conflict of interest: none.
PII: S1933-1711(09)00066-7
doi: 10.1016/j.jash.2009.05.001
© 2009 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Journal of the American Society of Hypertension
Volume 3, Issue 4
, Pages 238-244
, July 2009
