Journal of the American Society of Hypertension
Volume 3, Issue 3 , Pages 158-165, May 2009

Experimental animal models of hypertension

  • Kiran V. Sarikonda, MD

      Affiliations

    • College of Human Medicine, Michigan State University, East Lansing, Michigan, USA
    • ,
  • Ralph E. Watson, MD, FACP

      Affiliations

    • College of Human Medicine, Michigan State University, East Lansing, Michigan, USA
    • Corresponding Author InformationCorresponding author: Ralph E. Watson, MD, FACP, Hypertension Clinic, B338 Clinical Center, College of Human Medicine, Michigan State University, East Lansing, Michigan 48824. Tel: 517-353-4811; fax: 517-432-1326.
    • ,
  • Oluchi C. Opara, MD

      Affiliations

    • College of Human Medicine, Michigan State University, East Lansing, Michigan, USA
    • ,
  • Donald J. DiPette, MD, FAHA

      Affiliations

    • University of South Carolina, School of Medicine, Columbia, South Carolina, USA

Received 7 December 2008; accepted 12 February 2009. published online 09 April 2009.

Abstract 

Hypertension (HTN) and cardiovascular disease are the most common causes of death in developed countries. The use of experimental animal models of HTN has provided valuable information regarding many aspects of HTN, including etiology, pathophysiology, complications, and treatment. Because the etiology of HTN is heterogeneous, many experimental animal models have been developed to mimic the many facets of human HTN. The choice of animal model will be determined by the research question, monetary limitations, and technical expertise. The categories of models of HTN are: renovascular, renal parenchymal, pharmacologically induced, environmentally induced, and genetic. There are considerable differences between HTN in animals and humans, including differences in homeostatic mechanisms and pathophysiology; therefore, a thorough understanding of the animal models and rigorous analysis is required before extrapolating the finding in animals to humans.

Keywords: Renovascular, renal parenchymal, mineralocorticoid, genetic

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 This study was supported by the National Institute of Health Grant no. HL73251.

 Conflict of interest: none.

PII: S1933-1711(09)00012-6

doi:10.1016/j.jash.2009.02.003

Journal of the American Society of Hypertension
Volume 3, Issue 3 , Pages 158-165, May 2009

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