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Journal of the American Society of Hypertension
Volume 3, Issue 2
, Pages 105-112
, March 2009
Flavanols, the Kuna, cocoa consumption, and nitric oxide
References
- . Human population biology and hypertension. Evolutionary and ecological aspects of blood pressure. In: Laragh JH, Brenner BM editor. Hypertension: pathophysiology, diagnosis, and management. New York, New York: Raven Press, Ltd.; 1995;p. 115–127
- . The blood pressure of the Kuna Indians. Am J Trop Med Hyg. 1944;24:341–343
- . The Kuna gathering. Contemporary village politics in Panama. Austin, Texas: University of Texas Press; 1986;9–11
- Aging, acculturation, salt intake, and hypertension in the Kuna of Panama. Hypertension. 1997;29:171–176
- Stress and blood pressure in Kuna Amerinds. J Hypertension. 2005;7:714–720
- . Nutrition, diet, and hypertension. In: Coulston AM, Rock CL, Monsen ER editor. Nutrition in the prevention and treatment of disease. San Diego, California: Academic Press; 2001;p. 303–324
- Proximate, mineral, and procyanidin content of certain foods and beverages consumed by the Kuna Amerinds of Panama. J Food Comp Anal. 2001;14:553–563
- Hypertension, the Kuna, and the epidemiology of flavanols. J Cardiovasc Pharmacol Suppl. 2006;47:103–139
- A clinical trial of the effects of dietary patterns on blood pressure. N Engl J Med. 1997;336:1117–1124
- . Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertension. 2003;21:2281–2286
- Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. J Am Coll Nutr. 2004;23:197–204
- Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives. Hypertension. 2005;46:398–405
- . Chocolate and blood pressure in elderly individuals with isolated systolic hypertension. JAMA. 2003;290:1029–1030
- Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr. 2008;138:58–63
- . Acute dark chocolate and cocoa ingestion and endothelial function: a randomized controlled crossover trial. Am J Clin Nutr. 2008;88:58–63
- . Effect of cocoa and tea intake on blood pressure: a meta analysis. Arch Intern Med. 2007;167:626–634
- Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2008;88:38–50
- . Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study. Arch Intern Med. 2006;166:411–417
- . Treating prehypertension: a review of the evidence. Curr Hypertens Rep. 2008;10:326–329
- . Effects of cocoa extracts on endothelium-dependent relaxation. J Nutr Suppl. 2000;130:2105–2108
- (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Nat Acad Sci U S A. 2006;103:1024–1029
- . Organ systems dependent on nitric oxide and the potential for nitric oxide-targeted therapies in related diseases. J Clin Hypertension Suppl. 2006;4:63–73
- . Evidence that antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health. Curr Opin Lipid. 2002;13:14–49
- . Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr Suppl. 2005;81:317–325
- Erdman JWJ, Balentine D, Arab L, Beecher G, Dwyer JT, Folts J, et al. Flavonoids and heart health: proceedingsof the ILSI North America Flavonoids Workshop. May 31 to June 1, 2005, Washington, DC. J Nutr Suppl 2007;137:718–37.
- . Cocoa antioxidants and cardiovascular health. Am J Clin Nutr Suppl. 2005;81:298–303
- Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med. 1995;155:381–386
- Consumption of foods rich in flavonoids is related to a decreased cardiovascular risk in apparently healthy French women. J Nutr. 2004;134:923–926
- Intake of specific flavonoid classes and coronary heart disease—a case control study in Greece. Eur J Clin Nutr. 2004;58:1643–1648
- Intake of specific flavonoids and risk of acute myocardial infarction in Italy. Public Health Nutr. 2006;9:369–374
- . Relation between intake of flavonoids and risk for coronary heart disease in male health professionals. Ann Intern Med. 1996;125:384–389
- Dietary intakes of flavonols and flavones and coronary heart disease in U.S. women. Am J Epidemiol. 2007;165:1305–1313
- Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr. 2007;85:895–909
- . Antioxidant flavonols and ischemic heart disease in a Welsh population of men: the Caerphilly Study. Am J Clin Nutr. 1997;65:1489–1494
- . Catechin intake might explain the inverse relation between tea consumption and ischemic heart disease: the Zutphen Elderly Study. Am J Clin Nutr. 2001;74:227–232
- . Dietary catechins in relation to coronary heart disease death among postmenopausal women. Epidemiology. 2001;12:668–675
- . Cocoa intake, blood pressure, and cardiovascular mortality. Arch Intern Med. 2006;166:411–417
- U.S. Department of Agriculture. USDA—Iowa State University database on the isoflavone content of foods. 1999;
- U.S. Department of Agriculture. USDA database for the flavonoid content of selected foods. 2003;
- U.S. Department of Agriculture. USDA database for the proanthocyanidin content of selected foods. 2004;
- . Analysis of flavanols in foods: what methods are required to enable meaningful health recommendations?. J Cardiovasc Pharmacol Suppl. 2006;47:110–118
- . Does flavanol intake influence mortality from nitric oxide-dependent processes? Ischemic heart disease, stroke, diabetes mellitus, and cancer in Panama. Int J Med. 2007;4:53–58
- Rationale and design of the dietary approaches to stop hypertension trial (DASH): a multicenter controlled feeding study of dietary patterns to lower blood pressure. Am J Epidemiol. 1995;5:108–118
This study was supported by Grants from M&M Mars, Inc.
Conflict of interest: none.
PII: S1933-1711(08)00216-7
doi: 10.1016/j.jash.2008.11.001
© 2009 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.
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Journal of the American Society of Hypertension
Volume 3, Issue 2
, Pages 105-112
, March 2009
