Journal of the American Society of Hypertension
Volume 3, Issue 2 , Pages 133-140 , March 2009

Development of cardiomyopathy and atrial tachyarrhythmias associated with activating autoantibodies to beta-adrenergic and muscarinic receptors

  • Xichun Yu, MD

      Affiliations

    • Heart Rhythm Institute, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma, USA
    • Endocrinology, Department of Medicine, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma, USA
    • ,
  • Eugene Patterson, PhD

      Affiliations

    • Heart Rhythm Institute, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma, USA
    • Department of Cell Biology, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma, USA
    • ,
  • Stavros Stavrakis, MD

      Affiliations

    • Heart Rhythm Institute, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma, USA
    • ,
  • Shijun Huang, MD

      Affiliations

    • Heart Rhythm Institute, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma, USA
    • Endocrinology, Department of Medicine, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma, USA
    • ,
  • Isabel De Aos, PhD

      Affiliations

    • Heart Rhythm Institute, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma, USA
    • ,
  • Sean Hamlett, MD

      Affiliations

    • Endocrinology, Department of Medicine, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma, USA
    • ,
  • Madeleine W. Cunningham, PhD

      Affiliations

    • Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma, USA
    • ,
  • Ralph Lazarra, MD

      Affiliations

    • Heart Rhythm Institute, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma, USA
    • ,
  • David C. Kem, MD

      Affiliations

    • Heart Rhythm Institute, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma, USA
    • Endocrinology, Department of Medicine, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma, USA
    • Department of Geriatric Medicine, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, Oklahoma, USA
    • Corresponding Author InformationCorresponding author: David C. Kem, MD, ET6E103, 1200 Everett Drive Oklahoma City, Oklahoma 73104. Tel: 405-271-5896; fax: 405-271-7455.

Received 8 August 2008 ,Accepted 15 October 2008.

References 

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  3. Rosenbaum MB, Chiale PA, Schejtman D, Levin M, Elizari MV. Antibodies to beta-adrenergic receptors disclosing agonist-like properties in idiopathic dilated cardiomyopathy and Chagas' heart disease. J Cardiovasc Electrophysiol. 1994;5:367–375
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 This study was supported in part by Grants from the American Heart Association, the Presbyterian Health Foundation (Dr Yu), the Heart Rhythm Institute, OUHSC, and the Veterans Administration Research Foundation (Drs. Kem and Patterson) and by individual Grants from Helen and Will Webster and Britani and Paul Bowman.

 Conflict of interest: none.

PII: S1933-1711(08)00186-1

doi: 10.1016/j.jash.2008.10.004

Journal of the American Society of Hypertension
Volume 3, Issue 2 , Pages 133-140 , March 2009

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