Journal of the American Society of Hypertension
Volume 2, Issue 5 , Pages 326-331 , September 2008

Subfornical organ mediates pressor effect of angiotensin: Influence of nitric oxide synthase inhibitors, AT1 and AT2 angiotensin antagonist's receptors

  • Wilson Abrão Saad, MD

      Affiliations

    • Basic Institute of Biosciences-UNITAU, Taubaté, São Paulo, Brazil
    • Department of Exact and Natural Science UNIARA Araraquara, São Paulo, Brazil
    • Department of Physiology and Pathology School of Dentistry, Paulista State University, UNESP Araraquara, São Paulo, Brazil
    • Department of Physiology, Federal University of São Carlos, São Paulo, Brazil
    • Corresponding Author InformationCorresponding author: Wilson Abrão Saad, MD, Department of Physiology and Pathology, School of Dentistry, Paulista State University, UNESP, Rua Humaitá, 1680, 14801-903-Araraquara, São Paulo, Brazil. Tel: +55(16) 3301 6488; fax: +55(16) 3322 0836
  • ,
  • Luiz Antonio de Arruda Camargo

      Affiliations

    • Department of Physiology and Pathology School of Dentistry, Paulista State University, UNESP Araraquara, São Paulo, Brazil
    • Department of Physiology, Federal University of São Carlos, São Paulo, Brazil
  • ,
  • Ismael Francisco Motta Siqueira Guarda, MD

      Affiliations

    • Department of Anesthesiology Clinic Hospital State of São Paulo, São Paulo, Brazil
  • ,
  • Talmir Augusto Faria Brizola dos Santos

      Affiliations

    • Basic Institute of Biosciences-UNITAU, Taubaté, São Paulo, Brazil

Received 19 February 2008 ,Accepted 10 April 2008.

References 

  1. Bickerton RK, Bucley JP. Evidence for a central mechanism in angiotensin induced hypertension. Proc Exp Biol Med. 1961;106:834–836
  2. Von Bohlen Und Halbach O, Albrecht D. The CNS renin-angiotensin system. Cell Tissue Res. 2006;326:599–616
  3. Reid JA. Actions of angiotensin II on the brain: mechanisms and physiological role. Am J Physiol. 1988;246:F533–F543
  4. Saad WA, Gutierrez LI, Guarda IFSM, Camargo LAA, Santos TAFB, Saad WA, et al. Nitric oxide of the supraoptic nucleus influences the salivary secretion, sodium renal excretion, urinary volume and arterial blood pressure. Life Sci. 2004;74:1593–1603
  5. Mangiapane ML, Simpson JB. Subfornical organ: forebrain site of pressor and dipsogenic action of angiotensin II. Am J Physiol. 1980;239:R382–R389
  6. Thunhorst RL, Erlich KJ, Simpson JB. Subfornical organ participates in salt appetite. Behav Neurosci. 1990;104:637–642
  7. Yang H, Lu D, Raizafa MK. Lack of cross talk between α1-adrenergic and angiotensin type 1 receptors in neurons of spontaneous hypertensive rats. Hypertension. 1996;27:1277–1283
  8. Cunningham JT, Johnson AK. Decreased norepinephrine in the ventral lamina terminalis region is associated with angiotensin II drinking responses deficits following local 6-hydroxidopamine injections. Brain Res. 1989;480:65–71
  9. Gardiner TW, Stricker EM. Impaired drinking responses of rats with lesions of nucleus medianus: circadian dependence. Am J Physiol. 1985;248:R224–R230
  10. Lind RW, Johnson AK. Subfornical organ-median preoptic connections and drinking and pressor responses to angiotensin II. J Physiol. 1982;228:295–301
  11. Saad WA, Camargo LAA, Guarda RS, Pereira AF, Simões S. Effect of injection of L-NAME on drinking response. Braz J Med Biol Res. 1999;32:1413–1416
  12. Ku YK, Li YH. Subfornical organ-angiotensin II pressor system takes part on pressor response of emotional circuit. Peptides. 2003;24:1063–1067
  13. Collister JP, Hendel MD. Chronic effects of angiotensin II and AT1 receptor antagonists in subfornical organ-lesioned rats. Clin Exp Pharmacol Physiol. 2005;32:462–466
  14. Li M, Wang QS, Chen Y, Wang ZM, Liu Z, Guo SM. [Resveratrol inhibits the electrical activity of subfornical organ neurons in rat.]. Sheng Li Xue Bao. 2005;57:523–528
  15. Pesini P, Rois JL, Menendez L, Vidal S. The neonatal treatment of rats with monosodium glutamate induces morphological changes in the subfornical organ. Anat Histol Embryol. 2004;33:273–277
  16. Saad WA, Guarda IFMS, Camargo LAA, Santos TAFB, Guarda RS, Simões S, et al. Role of nitric oxide of the median preoptic nucleus (MnPO) on the alterations of salivary flow, arterial pressure and heart rate induced by injection of pilocarpine into MnPO and intraperitoneally. Braz J Med Biol Res. 2003;36:897–905
  17. Saad WA, Camargo LAA, Guarda IFMS, Saad WA. L-type calcium channel mediate water intake induced by angiotensin injection into median preoptic nucleus. Pharmacol Biochem Behav. 2006;83:598–602
  18. Hodge G, Ye VZ, Duggan KA. Salt-sensitive hypertension resulting from nitric oxide synthase inhibition is associated with loss of regulation of angiotensin II in the rat. Exp Physiol. 2002;87:1–8
  19. Bush MA, Pollack GM. Pharmacokinetics and pharmacodynamics of 7-nitroindazole, a selective nitric oxide synthase inhibitor, in the rat hippocampus. Pharmacol Res. 2001;18:1607–1610
  20. Ghosh A, Greenberg ME. Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science. 1995;268:239–247
  21. Tsien RW, Lipscombe D, Madison DV, Bley KR, Fox AP. Multiple types of neuronal calcium channels and their selective modulation. Trends Neurosci. 1988;11:431–438
  22. Zhu B, Herbert J. Calcium channels mediate angiotensin II-induced drinking behaviour and c-fos expression in the brain. Brain Res. 1997;778:206–214
  23. Washburn DL, Ferguson AV. Selective potentiation of N-type calcium channels by angiotensin II in rat subfornical organ neurons. J Physiol. 2001;536:667–675
  24. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. New York, New York: Academic Press; 1986;
  25. Mckinley MJ, Albiston AL, Allen AM, May CN, McAllen RM, Oldfield BJ, et al. The brain renin-angiotensin system: location and physiological roles. Int J Biochem Cell Biol. 2003;35:901–918
  26. Saad WA, Gutierrez LI, Guarda IFSM, Camargo LAA, Santos TAFB, Saad WA, et al. Lateral hypothalamus lesions influences water and salt intake, and sodium and urine excretion, arterial blood pressure induced by L-NAME and FK 409 injections into median preoptic nucleus in conscious rats. Life Sci. 2004;75:685–697
  27. Camara AK, Osborn J. Central AT1 and AT2 receptors mediate chronic intracerebroventricular angiotensin II-induced drinking in rats fed high sodium chloride diet from weaning. Acta Physiol Scand. 2001;171:195–201
  28. Wang G, Anrather J, Michael J, Glass M, Tarsitano J, Zhou P, et al. Nox2, Ca2+, and protein kinase C play a role in angiotensin II-induced free radical production in nucleus tractus solitarius. Hypertension. 2006;48:482–489
  29. Zhu B, Herbert J. Angiotensin II interacts with nitric oxide cyclic GMP pathway in the central control of drinking behavior: mapping with c-fos and NADPH-diaphorase. Neuroscience. 1997;79:543–553
  30. Rauch M, Schmid HA, de Vente J, Simon E. Electrophysiological and immunocytochemical evidence for a cGMP-mediated inhibition of subfornical organ neurons by nitric oxide. J Neurosci. 1997;17:363–371
  31. Tanaka T, Saito H, Matsuki N. Endogenous nitric oxide inhibits NMDA- and kainite-response by a negative feedback system in rat hippocampal neurons. Brain Res. 1993;631:72–76

 This study was supported by CNPq, FAPESP, FUNADESP-UNIARA, PRONEX, and FUNDUNESP.

 Conflict of interest: none.

PII: S1933-1711(08)00051-X

doi: 10.1016/j.jash.2008.04.007

Journal of the American Society of Hypertension
Volume 2, Issue 5 , Pages 326-331 , September 2008