Journal of the American Society of Hypertension
Volume 2, Issue 5 , Pages 378-384 , September 2008

Effects of metoprolol succinate extended release vs. amlodipine besylate on the blood pressure, heart rate, and the rate-pressure product in patients with hypertension

  • William B. White, MD

      Affiliations

    • Corresponding Author InformationCorresponding author: William B. White, MD, Professor and Division Chief, Division of Hypertension and Clinical Pharmacology, Calhoun Cardiology Center, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030. Tel: 860-679-2104; fax: 860-679-1250
    • ,
  • Subramanian Krishnan, MD
    • ,
  • Sharon Giacco, RN
    • ,
  • Madhavi Mallareddy, MD

Received 15 February 2008 ,Accepted 11 March 2008.

References 

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  3. White WB. Methods of blood pressure determination to assess antihypertensive therapy (Are casual measurements enough?). Clin Pharmacol Ther. 1989;45:581–586
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  5. Marler JR, Price TR, Clark GL, Muller JE, Robertson T, Mohr JP, et al. Morning increase in the onset of ischemic stroke. Stroke. 1989;20:473–476
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  9. White WB, Black HR, Weber MA, Elliott WJ, Bryzinski B, Fakouhi TD. Comparison of effects of controlled onset extended release verapamil at bedtime and nifedipine gastrointestinal therapeutic system on arising on early morning blood pressure, heart rate, and the heart-rate blood pressure product. Am J Cardiol. 1998;81:424–431
  10. White WB. Advances in ambulatory blood pressure monitoring to assess the effects of antihypertensive therapy. In:  White WB editors. Blood pressure monitoring in cardiovascular medicine and therapeutics. 2nd edition. Totowa, New Jersey: Humana Press; 2007;p. 437–462
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  21. White WB, Sica DA, Calhoun D, Mansoor GA, Anders RJ. Preventing increases in early-morning blood pressure, heart rate, and the rate-pressure product with controlled onset extended release verapamil at bedtime versus enalapril, losartan, and placebo on arising. Am Heart J. 2002;144:657–665
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  24. Frishman WH, Hainer JW, Sugg J. A factorial study of combination hypertension treatment with metoprolol succinate extended release and felodipine extended release. Am J Hypertens. 2006;19:388–395

 This study was supported by an Independent Investigator Initiated Grant-in-Aid (IRUSMETO-0079) from Astra-Zeneca Pharmaceuticals, Inc, Wilmington, Delaware, the Patrick and Catherine Weldon Donaghue Foundation, Hartford, Connecticut, and the University of Connecticut Clinical Trials Unit, Farmington, Connecticut.

 Conflict of interest: none.

PII: S1933-1711(08)00035-1

doi: 10.1016/j.jash.2008.03.002

Journal of the American Society of Hypertension
Volume 2, Issue 5 , Pages 378-384 , September 2008

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