Journal of the American Society of Hypertension
Volume 2, Issue 4 , Pages 267-274 , July 2008

Children and adolescents with obesity-associated high blood pressure

  • Bonita Falkner, MD

      Affiliations

    • Corresponding Author InformationCorresponding author: Bonita Falkner, MD, Division of Nephrology, 833 Chestnut Street, Suite 700, Philadelphia, Pennsylvania 19107. Tel: 215-503-2501; fax: 215-503-2506.

Received 23 August 2007 ,Accepted 2 January 2008.

References 

  1. Still JL, Cottom D. Severe hypertension in childhood. Arch Dis Child. 1967;42:34–39
  2. Pickering TG, Hall JE, Appel LJ, Falkner B, Graves J, Hill MN, et al. Recommendations for blood pressure measurement in humans and experimental animals: part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Circulation. 2005;111:697–716
  3. National High Blood Pressure Education Program Working Group on high blood pressure in children and adolescents. The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents. Pediatrics. 2004;114:555–576
  4. Hansen ML, Gunn PW, Kaelber DC. Underdiagnosis of hypertension in children and adolescents. JAMA. 2007;298:874–879
  5. McNiece KL, Poffenbarger TS, Turner JL, Fanco KD, Sorof JM, Portman RJ. Prevalence of hypertension and prehypertension among adolescents. J Pediatr. 2007;150:640–644
  6. Ogden CL, Flegel KM, Carroll MD, Johnson CL. Prevalence and trends in overweight among US children and adolescents, 1999–2000. JAMA. 2002;288:1728–1732
  7. Munter P, He J, Cutler JA, Wildman RP, Whelton PK. Trends in blood pressure among children and adolescents. JAMA. 2004;291:2107–2113
  8. Falkner B, Gidding SS, Ramirez-Garnica G, Wiltrout SA, West D, Rappaport EB. The relationship of body mass index with blood pressure in primary care pediatric patients. J Pediatr. 2006;148:195–200
  9. Cook NR, Gillman MW, Rosner BA, Taylor JO, Hennekens CH. Prediction of young adult blood pressure from childhood blood pressure, height, and weight. J Clin Epidemiol. 1997;50:571–579
  10. Lauer RM, Mahoney LT, Clarke WR. Tracking of blood pressure during childhood: the Muscatine Study. Clin Exp Hypertens. 1986;8:515–537
  11. Falkner B, Hulman S, Kushner H. Birth weight vs childhood growth as determinants of adult blood pressure. Hypertension. 1998;32:145–150
  12. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999–2004. JAMA. 2006;295:1549–1555
  13. Thomas F, Bean K, Pannier B, Opert J-M, Guize L, Benetos A. Cardiovascular mortality in overweight subjects (The key role of associated risk factors). Hypertension. 2005;46:654–659
  14. Burns TL, Moll PP, Lauer RM. Increased familial cardiovascular mortality in obese schoolchildren: the Muscatine Ponderosity Family Study. Pediatrics. 1992;89:262–268
  15. Fox E, Taylor H, Andrew M, Han H, Mohamed E, Garrison R, et al. Body mass index and blood pressure influences on left ventricular mass and geometry in African-Americans (The Atherosclerotic Risk in Communities (ARIC) Study). Hypertension. 2004;44:55–60
  16. Drukteinis JS, Roman MJ, Fabsitz RR, Lee ET, Best LG, Russel M, et al. Cardiac and systemic hemodynamic characteristics of hypertension and prehypertension in adolescents and young adults (The Strong Heart Study). Circulation. 2007;115:221–227
  17. Sorof JM, Turner J, Martin DS, Garcia K, Garami Z, Alexandrov AV, et al. Cardiovascular risk factors and sequelae in hypertensive children identified by referral versus school-based screening. Hypertension. 2004;43:214–218
  18. Lande MB, Carson NL, Roy J, Meagher CC. Effects of childhood primary hypertension on carotid intima media thickness: a matched controlled study. Hypertension. 2006;48:1–5
  19. Pausova Z, Gaudet D, Gossard F, Bernard M, Kaldunski ML, Jomphe M, et al. Genome-wide scan for linkage to obesity-associated hypertension in French Canadians. Hypertension. 2005;46:1280–1285
  20. Reaven G. Role of insulin resistance in human disease. Diabetes. 1988;37:1595–1607
  21. Meigs JB. Invited commentary: insulin resistance syndrome? (Syndrome X? Multiple metabolic syndrome? A syndrome at all? Factor analysis reveals patterns in the fabric of correlated metabolic risk factors). Am J Epidemiol. 2000;152:908–911
  22. Yip J, Facchini FS, Reaven GM. Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease. J Clin Endocrinol Metab. 1998;83:2773–2776
  23. Falkner B, Onesti G, Angelakos ET, Fernandez M, Langman C. Cardiovascular response to mental stress in normal adolescents with hypertensive parents. Hypertension. 1979;1:23–30
  24. Rocchini AP, Key J, Bondie D, Chico R, Moorehead C, Katch V, et al. The effect of weight loss on the sensitivity of blood pressure to sodium in obese adolescents. N Engl J Med. 1989;321:580–585
  25. Harshfield GA, Wilson ME, McLeod K, Hanevold C, Papuku GK, Mackey L, et al. Adiposity is related to gender differences in impaired stress-induced pressure natriuresis. Hypertension. 2003;42:1082–1086
  26. Wilson ME, Harshfield GA, Ortiz L, Hanevold C, Kapuka G, Mackey L, et al. Relationship of body composition to stress-induced pressure natriuresis in youth. Am J Hypertens. 2004;17:1023–1028
  27. Julius S. Cocoran lecture: sympathetic hyperactivity and coronary risk in hypertension. Hypertension. 1993;21:886–893
  28. Sun SS, Grave GD, Siervogel RM, Pickoff AA, Arslanian SS, Daniels SR. Systolic blood pressure in childhood predicts hypertension and metabolic syndrome later in life. Pediatrics. 2007;119:237–246
  29. Reaven GM. The metabolic syndrome: is this diagnosis necessary?. Am J Clin Nutr. 2006;83:1237–1247
  30. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–2487
  31. Alberti KG, Zimmer PZ. Definition, diagnosis and classification of diabetes mellitus and its complications, I: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetes Med. 1998;15:539–553
  32. Cook S, Weitzman M, Auinger P, Nguyen M, Dietz W. Prevalence of a metabolic syndrome phenotype in adolescents. Arch Pediatr Adolesc Med. 2003;157:821–827
  33. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med. 2004;350:2362–2374
  34. Sorof J, Daniels S. Obesity hypertension in children (A problem of epidemic proportions). Hypertension. 2002;40:441–447
  35. Kahn R, Buse J, Ferrannini E, Stern M. The metabolic syndrome: time for a critical appraisal. Diabetes Care. 2005;28:2289–2304
  36. Bao W, Srinivasan SR, Wattigney WA, Berenson GS. Persistence of multiple cardiovascular risk clustering related to syndrome X from childhood to young adulthood (The Bogalusa Heart Study). Arch Intern Med. 1994;154:1842–1847
  37. Katzmarzyk PT, Perusse L, Malina RM, Bergeron J, Despres JP, Bouchard C. Stability of indicators of the metabolic syndrome from childhood and adolescence to young adulthood: the Quebec Family Study. J Clin Epidemiol. 2001;54:190–195
  38. Raitakari OT, Juonala M, Kahonen M, Taittonen L, Laitinen T, Maki-Torkko N, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA. 2003;290:2277–2283
  39. Daniels SR, Loggie JMH, Khoury P, Kimball TR. Left ventricular geometry and severe left ventricular hypertrophy in children and adolescents with essential hypertension. Circulation. 1998;97:1907–1911
  40. Hanevold C, Waller J, Daniels S, Portman R, Sorof J. The effects of obesity, gender, and ethnic group on left ventricular hypertrophy and geometry in hypertensive children: a collaborative study of the International Pediatric Hypertension Association. Pediatrics. 2004;113:328–333
  41. Rocchini AP, Moorehead C, Katch V, Key J, Finta KM. Forearm resistance vessel abnormalities and insulin resistance in obese adolescents. Hypertension. 1992;19:615–620
  42. Oren A, Vos LE, Uiterwaal CSPM, Gorissen WHM, Grobbee DE, Bots ML. Change in body mass index from adolescence to young adulthood and increased carotid intima-media thickness at 28 years of age: the Atherosclerosis Risk in Young Adults Study. Int J Obes. 2003;27:1383–1390
  43. Li S, Chen W, Srinivasan SR, Bond MG, Tang R, Urbina EM, et al. Childhood cardiovascular risk factors and carotid vascular changes in adulthood (The Bogalusa Heart Study). JAMA. 2003;290:2271–2276
  44. Sorof JM, Alexandrov AV, Garami Z, Turner JL, Grafe RE, Lai D, et al. Carotid ultrasonography for detection of vascular abnormalities in hypertensive children. Pediatr Nephrol. 2003;18:1020–1024
  45. Berenson GS, Wattigney WA, Tracy RE, Newman WP, Srinivasan SR, Webber LS, et al. Atherosclerosis of the aorta and coronary arteries and cardiovascular risk factors in persons aged 6 to 30 years and studied at necropsy (The Bogalusa Heart Study). Am J Cardiol. 1992;70:851–858
  46. McGill HC, McMahan CA, Malcom GT, Oalmann MC, Strong JP. Relation of glycohemoglobin and adiposity to atherosclerosis in youth (Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group). Arterioscler Thromb Vasc Biol. 1995;15:431–440
  47. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499–511
  48. Festa A, D'Agostino R, Howard G, Mykkanen L, Tracy RP, Haffner SM. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation. 2000;102:42–47
  49. McLaughlin T, Abbasi F, Lamendola C, Liang L, Reaven G, Schaaf P, et al. Differentiation between obesity and insulin resistance in the association with C-reactive protein. Circulation. 2002;106:2908–2912
  50. Moon YS, Kim DH, Song DK. Serum tumor necrosis factor-alpha levels and components of the metabolic syndrome in obese adolescents. Metab Clin Exper. 2004;53:863–867
  51. Warnberg J, Nova E, Moreno Lam Romeo J, Mesana MI, Ruiz JR, Ortega FB, et al. and the AVENA Study Group (Inflammatory proteins are related to total and abdominal adiposity in healthy adolescent population: the AVENA Study). Am J Clin Nutr. 2006;84:505–512
  52. Yoshida T, Kaneshi T, Shimabukuro T, Sunagawa M, Ohta T. Serum C-reactive protein and its relation to cardiovascular risk factors and adipocytokines in Japanese children. J Clin Endocrinol Metab. 2006;91:2133–2137
  53. Lambert M, Devlin EE, Paradis G, O'Loughlin J, Hanley JA, Levy E. C-reactive protein and features of the metabolic syndrome in a population-based sample of children and adolescents. Clin Chem. 2004;50:1762–1768
  54. Vikram NK, Misra A, Dwivedi M, Sharma R, Pandey RM, Luthra K, et al. Correlations of C-reactive protein levels with anthropometric profile, percentage of body fat and lipids in healthy adolescents and young adults in urban North India. Atherosclerosis. 2003;168:305–313
  55. Kelly A, Wetzsteon RJ, Kaiser DR, Steinberger J, Bank AJ, Dengel DR. Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exercise. J Pediatr. 2004;145:731–736
  56. Sinaiko AR, Steinberger J, Moran A, Prineas RJ, Vessby B, Basu S, et al. Relation of body mass index and insulin resistance to cardiovascular risk factors, inflammatory factors, and oxidative stress during adolescence. Circulation. 2005;111:1985–1991
  57. Kelly AS, Steinberger J, Kaiser DR, Olson TP, Bank AJ, Dengel DR. Oxidative stress and adverse adipokine profile characterize the metabolic syndrome in children. J Cardiometab Syndr. 2006;1:248–253
  58. de Ferranti SD, Gauvereau K, Ludwig DS, Newburger JW, Rifai N. Inflammation and changes in metabolic syndrome abnormalities in US adolescents: findings from the 1988–1994 and 1999–2000 National Health and Nutrition Examination Surveys. Clin Chem. 2006;52:1325–1330
  59. Ford ES. C-reactive protein concentration and cardiovascular disease risk factors in children (Findings from the National Health and Nutrition Examination Survey 1999–2000). Circulation. 2003;108:1053–1058
  60. Pittas AG, Joseph NA, Greenberg AS. Adipocytokines and insulin resistance. J Clin Endocrinol Metab. 2004;89:447–452
  61. Pickup JC, Chusney GD, Thomas SM, Burt D. Plasma interleukin-6, tumor necrosis factor alpha and blood cytokine production in type 2 diabetes. Life Sci. 2000;67:291–300
  62. Haffner SM, Mykkanen L, Rainwater DL, Karhapaa P, Laakso M. Is leptin concentration associated with the insulin resistance syndrome in nondiabetic men?. Obes Res. 1999;7:164–169
  63. Festa A, D'Agostino R, Tracy RP, Haffner SM. Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes. 2002;51:1131–1137
  64. Winkler G, Salamon F, Salamon D, Speer G, Simon K, Cseh K. Elevated serum tumor necrosis factor-alpha levels can contribute to the insulin resistance in type II (non-insulin-dependent) diabetes and in obesity. Diabetologia. 1998;41:860–861
  65. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab. 2001;86:1930–1935
  66. Arita Y, Kihara S, Ouchi N, Maeda K, Miyagawa J, Hotta K, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun. 1999;257:79–83
  67. Ouchi N, Kihara S, Arita Y, Nishida M, Matsuyama A, Okamota Y, et al. Adipocyte-derived plasma protein, adiponectin, suppress lipid accumulation and class A receptor expression in human monocyte-derived macrophages. Circulation. 2001;103:1057–1063
  68. Okamoto Y, Arita Y, Nishida M, Maraguchi M, Ouchi N, Takahashi M, et al. An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm Metab Res. 2000;32:47–50
  69. Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y, et al. Novel modulator for endothelial adhesion molecules adipocyte-derived plasma protein adiponectin. Circulation. 1999;100:2473–2476
  70. Goldstein BJ, Scalia R. Adiponectin: a novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab. 2004;89:2563–2568
  71. Yamamoto Y, Hirose H, Saito I, Tomita M, Taniyama M, Matsubara K, et al. Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population. Clin Sci (Lond). 2002;103:137–142
  72. Weiss R, Dufour S, Groszmann A, Petersen K, Dziura J, Taksali SE, et al. Low adiponectin levels in adolescent obesity: a marker of increased intramyocellular lipid accumulation. J Clin Endocrinol Metab. 2003;88:2014–2018
  73. Asayama K, Hayashibe H, Dobashi K, Uchida N, Nakane T, Kodera K, et al. Decrease in serum adiponectin level due to obesity and visceral fat accumulation in children. Obes Res. 2003;11:1072–1079
  74. Stefan N, Bunt JC, Salbe AD, Funahashi T, Matsuzawa Y, Tataranni PA. Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Clin Endocrinol Metab. 2002;87:4652–4656
  75. Bottner A, Kratzsch J, Muller G, Kapellen TM, Bluher S, Keller E, et al. Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels. J Clin Endocrinol Metab. 2004;89:4053–4061
  76. Degawa-Yamauchi M, Dilts JR, Bovenkerk JE, Saha C, Pratt JH, Considine RV. Lower serum adiponectin levels in African-American boys. Obes Res. 2003;11:1384–1390
  77. Shimabukuro M, Higa N, Asahi T, Oshiro Y, Takasu N, Tagawa T, et al. Hypoadiponectinemia is closely linked to endothelial dysfunction in man. J Clin Endocrinol Metab. 2003;88:3236–3240
  78. Fernandez-Real J-M, Castro A, Vazquez G, Casamitjana R, Lopez-Bermejo A, Penarroja G, et al. Adiponectin is associated with vascular function independent of insulin sensitivity. Diabetes Care. 2004;27:739–745
  79. Adamczak M, Wiecek A, Funahashi T, Chudek J, Kokot F, Matsuzawa Y. Decreased plasma adiponectin concentration in patients with essential hypertension. Am J Hypertens. 2003;16:72–75
  80. Kazumi T, Kawaguchi A, Sakai K, Hirano T, Gen Y. Young men with high-normal blood pressure have lower serum adiponectin, smaller LDL size, and higher elevated heart rate than those with optimal blood pressure. Diabetes Care. 2002;25:971–976
  81. Daniels SR, Lipman MJ, Burke MJ, Loggie JM. The prevalence of retinal vascular abnormalities in children and adolescents with essential hypertension. Am J Ophthalmol. 1991;111:205–208
  82. Mitchell P, Cheung N, de Haseth K, Taylor B, Rochtchina E, Amirul Islam FM, et al. Blood pressure and retinal arteriolar narrowing in children. Hypertension. 2007;49:1156–1162
  83. Baker JL, Olsen LW, Sorensen TIA. Childhood body-mass index and the risk of coronary heart disease in adulthood. N Engl J Med. 2007;357:2329–2337
  84. Bibbins-Domingo K, Coxson P, Pletcher MJ, Lightwood J, Goldman L. Adolescent overweight and future adult coronary heart disease. N Engl J Med. 2007;357:2371–2379

 Conflict of interest: none.

PII: S1933-1711(08)00005-3

doi: 10.1016/j.jash.2008.01.003

Journal of the American Society of Hypertension
Volume 2, Issue 4 , Pages 267-274 , July 2008

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