Journal of the American Society of Hypertension
Volume 2, Issue 4 , Pages 205-209 , July 2008

Renin/prorenin receptor, (P)RR, in end-organ damage: current issues in 2007

  • Tadashi Inagami, PhD

      Affiliations

    • Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    • Corresponding Author InformationCorresponding author: Tadashi Inagami, PhD, Department of Biochemistry, Vanderbilt University School of Medicine, 663 LH, 23rd Ave. South at Pierce, Nashville, Tennessee 37232. Tel: 615-322-4347; fax: 615-322-3201.
    • ,
  • Tsutomu Nakagawa, PhD

      Affiliations

    • Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    • ,
  • Atsuhiro Ichihara, MD, PhD

      Affiliations

    • Department of Internal Medicine, Keio University, Tokyo, Japan
    • ,
  • Fumiaki Suzuki, PhD

      Affiliations

    • Faculty of Applied Biological Science, Gifu University, Gifu, Japan
    • ,
  • Hiroshi Itoh, MD, PhD

      Affiliations

    • Department of Internal Medicine, Keio University, Tokyo, Japan

Received 6 November 2007 ,Accepted 20 December 2007.

References 

  1. Nguyen G, Delarue F, Berrou J, Rondeau E, Sraer JD. Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen. Kidney Int. 1996;50:1897–1903
  2. Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer JD. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002;109:1417–1427
  3. Suzuki F, Hayakawa M, Nakagawa T, Nasir UM, Ebihara A, Iwasawa A, et al. Human prorenin has “gate and handle” regions for its non-proteolytic activation. J Biol Chem. 2003;278:22217–22222
  4. Nabi AH, Uddin M, Nakagawa T, Iwata H, Ichihara A, Inagami T, et al. Role of “handle” region of prorenin prosegment in the non-proteolytic activation of prorenin by binding to membrane anchored (pro)renin receptor. Front Biosci. 2007;12:4810–4817
  5. Ichihara A, Hayashi M, Kaneshiro Y, Suzuki F, Nakagawa T, Tada Y, et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the “handle” region for non-proteolytic activation of prorenin. J Clin Invest. 2004;114:1128–1135
  6. Danser AHJ, Denium J. Renin, prorenin and putative (Pro)renin receptor. Hypertension. 2005;46:1069–1076
  7. Kaneshiro Y, Ichihara A, Takemitsu T, Sakoda M, Suzuki F, Nakagawa T, et al. Increased expression of cyclooxygenase-2 in renal cortex of human-prorenin-receptor-gene transgenic rats. Kidney Int. 2006;70:641–646
  8. Saris JJ, 'tHoen PA, Garrelds IM, Dekkers DH, den Dunnen JT, Lamers JM, et al. Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II. Hypertension. 2006;48:564–571
  9. Huang Y, Wongamorntham S, Kasting J, McQuillan D, Owens RT, Yu L, et al. Renin increases mesangial cell transforming growth factor-β1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int. 2006;69:105–113
  10. Huang Y, Noble N, Zhang J, Xu C, Border WA. Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells. Kidney Int. 2007;72:45–52
  11. Ichihara A, Suzuki F, Nakagawa T, Kaneshiro Y, Takemitsu T, Sakoda M, et al. Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor deficient mice. J Am Soc Nephrol. 2006;17:1950–1961
  12. Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Nakagawa T, Nishiyama A, et al. Contribution of non-proteolytically activated prorenin in glomeruli to hypertensive renal damage. J Am Soc Nephrol. 2006;17:2495–2503
  13. Susic D, Lippton H, Knight M, Frolich E. Cardiovascular effects of nonproteolytic activation of prorenin. Hypertension. 2006;48:e113
  14. Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Suzuki F, Nakagawa T, et al. Non-proteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension. 2006;47:894–900
  15. Kaneshiro Y, Ichihara A, Sakoda M, Takemitsu T, Nabi AH, Uddin MN, et al. Slowly progressive, angiotensin II-independent glomerulosclerosis in human-renin/prorenin-receptor-transgenic rats. J Am Soc Nephrol. 2007;18:1789–1795
  16. Burckle CA, Danser JAH, Muller DN, Garrelds IM, Gasc JM, Popova E, et al. Elevated blood pressure and heart rate in human renin receptor transgenic rats. Hypertension. 2006;47:552–556
  17. Veniant M, Menard J, Bruneval P, Morley S, Gonzales MF, Mullins J. Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver. J Clin Invest. 1996;98:1966–1970
  18. Nabi AHMN, Kageshima A, Uddin M, Nakagawa T, Park EY, Suzuki F. Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system. Int J Mol Med. 2006;18:483–488

 This work was supported by NIH Research Grant HL58205 and Research Grant 17390249 from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PII: S1933-1711(07)00277-X

doi: 10.1016/j.jash.2007.12.006

Journal of the American Society of Hypertension
Volume 2, Issue 4 , Pages 205-209 , July 2008

Article Tools