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Journal of the American Society of Hypertension
Volume 2, Issue 4
, Pages 239-266
, July 2008
Treating hypertension while protecting the vulnerable islet in the cardiometabolic syndrome
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- PPARγ-activating angiotensin type-1 receptor blockers induce adiponectin. Hypertension. 2005;46:137–143
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- Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice. Hypertension. 2004;43:1003–1010
- . Simvastatin and losartan enhance nitric oxide and reduce oxidative stress in salt–induced hypertension. Am J Hypertens. 2005;18:1496–1502
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- Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease (ONTARGET/TRANSCEND) trials. Am Heart J. 2004;148:52–61
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- Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003;348:1309–1321
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- . Effect of aldosterone blockade in patients with systolic left ventricular dysfunction: implications of the RALES and EPHESUS studies. Mol Cell Endocrinol. 2004;217:53–58
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- Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling. Endocrinology. 2007;148:3773–3780
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- . Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation. 2005;111:1012–1018
- . Antihypertensive efficacy of the oral direct renin inhibitor aliskiren as add-on therapy in patients not responding to amlodipine monotherapy. J Clin Hypertens. 2007;9:742–750
- . Direct renin inhibition with aliskiren in obese patients with arterial hypertension. Hypertension. 2007;49:1047–1055
- . Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomized, double-blind trial. Lancet. 2007;370:221–229
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This research was supported by NIH (RO1 HL73101-01A1), an investigator-initiated grant from Novartis Pharmaceuticals Corp., and the Veterans Affairs Merit System (0018) for Dr. Sowers.
PII: S1933-1711(07)00252-5
doi: 10.1016/j.jash.2007.12.002
© 2008 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.
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Journal of the American Society of Hypertension
Volume 2, Issue 4
, Pages 239-266
, July 2008
