Journal of the American Society of Hypertension
Volume 2, Issue 2 , Pages 59-63 , March 2008

Twenty years of the (pro)renin receptor

  • Geneviève Nguyen, MD, PhD

      Affiliations

    • Corresponding Author InformationCorresponding author: Geneviève Nguyen, MD, PhD, Institut de la Santé et de la Recherche Médicale, (INSERM) Unit 833 and Collège de France, Experimental Medecine Unit, 11 place Marcelin Berthelot, 75005, Paris, France. Tel: + 33(0)1 44 27 16 89; Fax: +33(0)1 44 27 16 91.

Received 29 October 2007 ,Accepted 3 December 2007.

References 

  1. Bright R. Cases and observations illustrative of renal disease accompanied with the secretion of albuminous urine. Guy’s Hosp Rep. 1836;1:338
  2. Tigerstedt R, Bergman PG. Niere und kreislauf. Scand Arch Physiol. 1898;8:223–271
  3. Goldblatt H, Lynch J, Hanzal RF, Summerville WW. Studies on experimental hypertension (I. The production of persistent elevation of systolic blood pressure by means of renal ischemia). J Exp Med. 1934;59:347–379
  4. Page IH, Helmer OM. A crystalline pressor substance: angiotonin. Proc Center Soc Clin Invest. 1939;12:17
  5. Braun-Menendez E, Fasciolo JC, Leloir LF, Munoz JM. La sustancia hipertensora de la sangre del rinon isquemiado. Rev Soc Arg Biol. 1939;15:420–425
  6. Carey RM, Siragy HM. Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation. Endocr Rev. 2003;24:261–271
  7. Swales JD, Loudon M, Bing RF, Thurston H. Renin in the arterial wall. Clin Exp Hypertens A. 1983;5:1127–1136
  8. Sealey JE, Glorioso N, Itskovitz J, et al. Ovarian prorenin. Clin Exper Theory Practice. 1987;A9:1435–1454
  9. Sealey JE, Rubattu S. Prorenin and renin as separate mediators of tissue and circulating system. Am J Hypertens. 1989;2:358–366
  10. Danser AH, Deinum J. Renin, prorenin and the putative (pro)renin receptor. Hypertension. 2005;46:1069–1076
  11. Danser AH. Prorenin:back into the arena. Hypertension. 2006;47:824–826
  12. Luetscher JA, Kraemer FB, Wilson DM, et al. Increased plasma inactive renin in diabetes mellitus a marker of microvascular complications. N Engl J Med. 1985;312:1412–1417
  13. Wilson DM, Luetscher JA. Plasma prorenin activity and complications in children with insulin-dependent diabetes mellitus. N Engl J Med. 1990;18:1101–1106323
  14. Methot D, Silversides DW, Reudelhuber TL. In vivo enzymatic assay reveals catalytic activity of the human renin precursor in tissues. Circ Res. 1999;84:1067–1072
  15. Véniant M, Ménard J, Bruneval P, et al. Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver. J Clin Invest. 1996;98:1966–1970
  16. Nguyen G, Delarue F, Burcklé C, et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002;109:1417–1427
  17. Zhang J, Noble NA, Border WA, Huang Y. Prorenin increases PAI1 expression in vascular smooth-muscle cells (VSMCs); effects that are renin/prorenin receptor-mediated, are markedly potentiated by angiotensinogen and are both AngII-independent and Ang II dependent. [abstract] J Am Soc Nephrol. 2007;18:F-PO297
  18. Mercure C, Thibault G, Lussier-Cacan S, et al. Molecular analysis of human prorenin prosegment variants in vitro and in vivo. J Biol Chem. 1995;270:16355–16359
  19. Nguyen G, Delarue F, Berrou J, et al. Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen. Kidney Int. 1996;50:1897–1903
  20. Huang Y, Wongamorntham S, Kasting J, et al. Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int. 2006;69:105–113
  21. Huang Y, Noble N, Zhang J, et al. Renin stimulated TGF-β1 expression is regulated by a mitogen-activated protein kinase in mesangial cells. Kidney Int. 2007;72:45–52
  22. Saris JJ, ’tHoen PAC, Garrelds IM, et al. Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II. Hypertension. 2006;48:564–571
  23. Xu J, Zhang MZ, Harris RC. Prorenin/renin receptor increases expression of cyclooxygenase-2 in mouse macula densa cells (F-FC105). [abstract] J Am Soc Nephrol. 2007;18:23A
  24. Schefe JH, Menk M, Reinemund J, et al. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res. 2006;99:1355–1366
  25. Hamming I, Contrepas A, Nguyen G, et al. Regulation of the renal renin/(pro)renin receptor by ACE-inhibition and sodium restriction. (abstract) J Am Soc Nephrol. 2005;16:120
  26. Huang Y, Border WA, Noble NA. Functional renin receptors in renal mesangial cells. Current Op Nephrol. 2007;9:133–139
  27. Krebs C, Hamming I, Sadaghiani S, et al. Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats. Kidney Int. 2007;72:725–730
  28. Ichihara A, Hayashi M, Kaneshiro Y, et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the “handle region” for nonproteolytic activation of prorenin. J Clin Invest. 2004;114:1128–1135
  29. Ichihara A, Suzuki F, Nakagawa T, et al. Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice. J Am Soc Nephrol. 2006;17:1950–1961
  30. Takahashi H, Ichihara A, Kaneshiro Y, et al. Regression of nephropathy developed in diabetes by (pro)renin receptor blockade. J Am Soc Nephrol. 2007;18:1789–1795
  31. Ichihara A, Kaneshiro Y, Takemitsu T, et al. Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension. 2006;47:894–900
  32. Ichihara A, Kaneshiro Y, Takemitsu T, et al. Contribution of nonprotelolytically activated prorenin in glomeruli of hypertensive renal damage. J Am Soc Nephrol. 2006;17:2495–2503
  33. Burcklé CA, Danser AHJ, Müller DN, et al. Elevated blood pressure and heart rate in human renin receptor transgenic rats. Hypertension. 2006;47:552–556
  34. Kaneshiro Y, Ichihara A, Takemitsu T, et al. Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats. Kidney Int. 2006;70:641–646
  35. Suzuki F, Hayakawa M, Nagakawa T, et al. Human prorenin has “gate and handle” regions for its non-proteolytic activation. J Biol Chem. 2003;278:22217–22222
  36. Price DA, Porter LE, Gordon M, Fisher ND, De’Oliveira JM, Laffel LM, et al. The paradox of the low-renin state in diabetic nephropathy. J Am Soc Nephrol. 1999;10:2382–2391
  37. Batenburg WW, Krop M, Garrelds IM, et al. Prorenin is the endogenous agonist of the (pro)renin receptor: binding kinetics of renin and prorenin in rat vascular smooth-muscle cells overexpressing the human receptor. [abstract] Hypertension. 2007;50:e76
  38. Feldt S, Maschke U, Dechend R, et al. Aliskiren, but not a (pro)renin receptor blocker, ameliorates angiotensin II-induced renal damage. [abstract] Hypertension. 2007;50:e88
  39. Ichihara A, Kaneshiro Y, Suzuki F. Prorenin receptor blockers: effects on cardiovascular complications of diabetes and hypertension. Expert Opin Investig Drugs. 2006;15:1137–1139
  40. Amsterdam A, Nissen RM, Sun Z, et al. Identification of 315 genes essential for early zebra fish development. Proc Natl Acad Sci U S A. 2004;101:12792–12797
  41. Ludwig J, Kersher S, Brandt U, Pfeiffer F, Fariha G, Apps DK, et al. Identification and characterization of a novel 9.2 kDa membrane sector-associated protein of vacuolar proton ATPase from chromaffin granules. J Biol Chem. 1998;273:10939–10947
  42. L’Huillier N, Sharp MGF, Dunbar DR, Mullins JJ. On the relationship between the renin receptor and the vacuolar proton ATPase membrane sector associated protein (M8-9). In: Frolich ED, Re RN, editors. The local cardiac renin angiotensin-aldosterone system. Springer, 17–34.
  43. Burckl C, Bader M. Prorenin and its ancient receptor. Hypertension. 2006;48:549–551
  44. Nguyen G, Contrepas A, Müller DN, et al. Effect of the renin inhibitor aliskiren on (pro)renin receptor and profibrotic gene expression in kidneys of diabetic TG(mRen-2)27 rats. [abstract] J Am Soc Nephrol. 2007;18:60a

 Dr. Nguyen has received a research Grant from Novartis.

 Conflict of interest: none.

PII: S1933-1711(07)00251-3

doi: 10.1016/j.jash.2007.12.001

Journal of the American Society of Hypertension
Volume 2, Issue 2 , Pages 59-63 , March 2008

Article Tools