Journal of the American Society of Hypertension
Volume 2, Issue 3 , Pages 173-181 , May 2008

Angiotensin-II-dependent NHE1 activation in human monocytes

  • Konstantinos Paletas, MD, PhD

      Affiliations

    • Metabolic Diseases Unit, Department of Internal Medicine, B'Medical Clinic, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • ,
  • Xenia Sailer, BSci

      Affiliations

    • Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • ,
  • Lina Rizeq, BSci

      Affiliations

    • Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • ,
  • Anastasia Dimitriadi

      Affiliations

    • Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • ,
  • George Koliakos, MD, PhD

      Affiliations

    • Laboratory of Biological Chemistry, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • ,
  • Martha Kaloyianni, PhD

      Affiliations

    • Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    • Corresponding Author InformationCorresponding author: Martha Kaloyianni, PhD, Aristotle University of Thessaloniki, School of Biology, Department of Zoology, Thessaloniki, Greece 54124. Tel: +30 2310 998271; fax: +30 2310 998269.

Received 10 July 2007 ,Accepted 25 October 2007.

References 

  1. Das UN. Is angiotensin-II an endogenous pro-inflammatory molecule?. Med Sci Monit. 2005;11:RA155–RA162
  2. Brasier AR, Jamaluddin M, Han Y, et al. Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-kB (NF-kB) transcription factor. Mol Cell Biochem. 2000;212:155–169
  3. Kumar KV, Das UN, Brasier AR, Jamaluddin M, Han Y, Patterson C, et al. Are free radicals involved in the pathobiology of human essential hypertension?. Free Rad Res Commun. 1993;19:59–66
  4. Baeuerle PA, Baltimore D. NF-kB (Ten years after). Cell. 1996;87:13–20
  5. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999;340:115–126
  6. Leite- Moreira AF, Castro-Chaves P, Pimentel- Nunes P, Lima-Carneiro A, Guerra MS, Soares JB, et al. Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect. Br J Pharmacol. 2006;147:690–697
  7. Reid AC, Mackins CJ, Sevedi N, Levi R, Silver RB. Coupling of angiotensin II AT1 receptors to neuronal NHE activity and carrier-mediated norepinephrine release in myocardial ischemia. Am J Physiol Heart Circ Physiol. 2004;286:H1448–H1454
  8. Koliakos G, Zolota Z, Paletas K, Kaloyianni M. High glucose concentrations stimulate human monocyte sodium/hydrogen exchanger activity and modulate atherosclerosis-related functions. Pflugers Arch. 2004;449:298–306
  9. Semplicini A, Ceolotto G, Felice M, Bordin L, Monuri A, Clari G, et al. Post-translational effects of protein kinase C and insulin on red cell membrane phosphorylation and cation heteroexchange in hypertension. Blood Press. 1996;1:55–58
  10. Plenz G, Robenek H. Monocytes/macrophages in atherosclerosis. Eur Cytokine Network. 1998;9:701–703
  11. Masereel B, Pochet L, Laeckmann D. An overview of inhibitors of Na(+)/H(+) exchanger. Eur J Med Chem. 2003;38:547–554
  12. Cuenda A, Alessi DR. Use of kinase inhibitors to dissect signaling pathways. Methods Mol Biol. 2000;99:161–175
  13. Goekjian PG, Jirousek MR. Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors, and agents in development. Curr Med Chem. 1999;6:877–903
  14. Rees DD, Palmer RM, Schulz R, Hodson HF, Moncada S. Characterization of three inhibitors of endothelial NO synthase in vitro and in vivo. Br J Pharmacol. 1990;101:746–752
  15. Seager-Danciger J, Lutz M, Hama S, Cruz D, Castrillo A, Lazaro J, et al. Method for large scale isolation, culture and cryopreservation of human monocytes suitable for chemotaxis, cellular adhesion assays, macrophage and dendritic cell differentiation. J Immunol Methods. 2004;288:123–134
  16. Incerpi S, Baldini P, Bellucci V, Zannetti A, Luly P. Modulation of the Na+/H+ antiport by insulin: interplay between protein kinase C, tyrosine kinase, and protein phosphatases. J Cell Physiol. 1994;159:205–212
  17. Thomas JA, Buchsbaum RN, Zimniak A, Racker E. Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry. 1979;18:2210–2218
  18. Verdegaal ME, Zegveld ST, van Furth R. Heat shock protein 65 induces CD62e, CD106 and CD54 on cultured human endothelial cells and increases their adhesiveness for monocytes and granulocytes. J Immunol. 1996;157:369–376
  19. Warnholtz A, Nickeng G, Schulz E, Macharzina R, Bräzen JH, Skatchkov M, et al. Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. Circulation. 1999;99:2027–2033
  20. Sandmann S, Yu M, Kaschina E, Blume A, Bouzinova E, Aalkjaer C, et al. Differential effects of angiotensin AT1 and AT2 receptors on the expression, translation and function of the Na+-H+ exchanger and Na+-HCO3-symporter in the rat heart after myocardial infarction. J Am Coll Cardiol. 2001;37:2154–2165
  21. Irani K. Oxidant signaling in vascular cell growth, death, and survival (A review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling). Circ Res. 2000;87:179–183
  22. Yamagishi SI, Edelstein D, Du XL, Kaneda Y, Guzman M, Brownlee M. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem. 2001;276:25096–25100
  23. Inoguchi T, Sonta T, Tsubouchi H, Etoh T, Kakimoto M, Sonoda N, et al. Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase. J Am Soc Nephrol. 2003;14(8 suppl 3):S227–S232
  24. Konstantinidis D, Koliakos G, Vafia K, Liakos P, Bantekas C, Trachana V, et al. Inhibition of the Na+/H+ exchanger isoform-1 and the extracellular signal-regulated kinase induces apoptosis: a time course of events. Cell Physiol Biochem. 2006;18:211–222
  25. Ceolotto G, Gallo A, Miola M, Sartori M, Trevisan R, Del Prato S, et al. Protein kinase C activity is acutely regulated by plasma glucose concentration in human monocytes in vivo. Diabetes. 1999;48:1316–1322
  26. Siffert W, Dusing R. Na+/H+ exchange in hypertension and in diabetes mellitus-facts and hypotheses. Basic Res Cardiol. 1996;91:179–190
  27. Fortuno A, Tisaire J, Lopez R, Bueno J, Diez J. Angiotensin converting enzyme inhibition corrects Na+/H+ exchanger overactivity in essential hypertension. Am J Hypertens. 1997;10:84–93
  28. Touyz RM, Schiffrin EL. Activation of the Na+/H+ exchanger modulates angiotensin II-stimulated Na(+)-dependent Mg2+ transport in vascular smooth muscle cells in genetic hypertension. Hypertension. 1999;34:442–449
  29. Bamosa AO. Blockade of Na+/H+ exchanger contracts the portal vein of spontaneously hypertensive and Wistar Kyoto rats. Indian J Physiol Pharmacol. 1997;41:211–218
  30. Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, et al. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes. 2000;49:1939–1945
  31. Villa-Abrille MC, Cingolani HE, Garciarena CD, Ennis IL, Aiello EA. Angiotensin II-induced endothelin-1 release in cardiac myocytes. Medicina (B Aires). 2006;66:229–236
  32. Putney LK, Denker SP, Barber DL. The changing face of the Na+/H+ exchanger, NHE1: structure, regulation, and cellular actions. Annu Rev Pharmacol Toxicol. 2002;42:527–552
  33. Sharma A, Singh M. Na+/H+ exchanger: an emerging therapeutic target in cardiovascular disorders. Drugs Today (Barc). 2000;36:793–802
  34. Teiwes J, Toto RD. Epithelial sodium channel inhibition in cardiovascular disease (A potential role for amiloride). Am J Hypertens. 2007;20:109–117

 This work was supported by Hellenic Society of Hypertension.

 Conflict of interest: none.

PII: S1933-1711(07)00228-8

doi: 10.1016/j.jash.2007.10.010

Journal of the American Society of Hypertension
Volume 2, Issue 3 , Pages 173-181 , May 2008