Journal of the American Society of Hypertension
Volume 2, Issue 1 , Pages 15-19 , January 2008

Critical roles of (pro)renin receptor-bound prorenin in diabetes and hypertension: sallies into therapeutic approach

  • Atsuhiro Ichihara, MD, PhD, FAHA

      Affiliations

    • Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    • Corresponding Author InformationCorresponding author: Atsuhiro Ichihara, MD, PhD, FAHA, Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Tel: +81-3-5363-3796; fax: +81-3-3359-2745.
    • ,
  • Hiroshi Itoh, MD, PhD

      Affiliations

    • Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Tadashi Inagami, PhD

      Affiliations

    • Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

Received 29 June 2007 ,Accepted 13 August 2007.

References 

  1. Nabi AHMN, Uddin M, Nakagawa T, Iwata H, Ichihara A, Inagami T, et al. Role of “handle” region of prorenin prosegment in the non-proteolytic activation of prorenin by binding to membrane anchored (pro)renin receptor. Front Biosci. 2007;12:4810–4817
  2. Suzuki F, Hayakawa M, Nakagawa T, Nasir UM, Ebihara A, Iwasawa A, et al. Human prorenin has “gate and handle” regions for its non-proteolytic activation. J Biol Chem. 2003;278:22217–22222
  3. Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer J-D. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002;109:1417–1427
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  10. Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Nakagawa T, Nishiyama A, et al. Contribution of non-proteolytically activated prorenin in glomeruli to hypertensive renal damage. J Am Soc Nephrol. 2006;17:2495–2503
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  13. Takahashi H, Ichihara A, Kaneshiro Y, Inomata K, Sakoda M, Takemitsu T, et al. Regression of nephropathy developed in diabetes by (pro)renin receptor blockade. J Am Soc Nephrol. 2007;18:2054–2061
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  22. Susic D, Lippton H, Knight M, Frohlich ED. Cardiovascular effects of nonproteolytic activation of prorenin. Hypertension. 2006;48:e113
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  24. Saris J, ’tHoen P, Garrelds I, Dekkers D, denDunnen J, Lamers J, et al. Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II. Hypertension. 2006;48:564–571
  25. Burckle CA, Jan Danser AH, Muller DN, Garrelds IM, Gasc JM, Popova E, et al. Elevated blood pressure and heart rate in human renin receptor transgenic rats. Hypertension. 2006;47:1–5
  26. Kaneshiro Y, Ichihara A, Sakoda M, Takemitsu T, Nabi AN, Uddin MN, et al. Slowly progressive, angiotensin II-independent glomerulosclerosis in human-renin/prorenin-receptor-transgenic rats. J Am Soc Nephrol. 2007;18:1789–1795
  27. Kaneshiro Y, Ichihara A, Takemitsu T, Sakoda M, Suzuki F, Nakagawa T, et al. Increased expression of cyclooxygenase-2 in renal cortex of human-prorenin-receptor-gene transgenic rats. Kidney Int. 2006;70:641–646

 This work was supported, in part, by a grant from the Ministry of Education, Science and Culture of Japan (16790474 and 17390249).

 Conflict of interest: none.

PII: S1933-1711(07)00167-2

doi: 10.1016/j.jash.2007.08.001

Journal of the American Society of Hypertension
Volume 2, Issue 1 , Pages 15-19 , January 2008

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