Journal of the American Society of Hypertension
Volume 2, Issue 1 , Pages 39-43 , January 2008

TROPHY study: Outcomes based on the Seventh Report of the Joint National Committee on Hypertension definition of hypertension

  • Stevo Julius, MD, ScD

      Affiliations

    • University of Michigan, Ann Arbor, Michigan, USA
    • Corresponding Author InformationCorresponding author: Stevo Julius, MD, ScD, Emeritus Professor of Medicine and Physiology, University of Michigan, 24 Frank Lloyd Wright Drive, Lobby M, Ann Arbor, Michigan 48106. Tel: 734-998-7955; fax: 734-998-8018.
    • ,
  • Niko Kaciroti, PhD

      Affiliations

    • University of Michigan, Ann Arbor, Michigan, USA
    • ,
  • Brent M. Egan, MD

      Affiliations

    • Medical University of South Carolina, Charleston, South Carolina, USA
    • ,
  • Shawna Nesbitt, MD

      Affiliations

    • University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    • ,
  • Eric L. Michelson, MD

      Affiliations

    • AstraZeneca, Wilmington, Delaware, USA
    • ,
  • Trial of Preventing Hypertension (TROPHY) Investigators

Received 3 July 2007 ,Accepted 20 July 2007.

References 

  1. Julius S, Nesbitt SD, Egan BM, et al. Trial of Preventing Hypertension (TROPHY) Study Investigators Feasibility of treating prehypertension with an angiotensin-receptor blocker. N Engl J Med. 2006;354:1685–1697
  2. Schunkert H. Pharmacotherapy for prehypertension-mission accomplished?. N Engl J Med. 2006;354:1742–1744
  3. Persell SD, Baker DW. Studying interventions to prevent the progression from prehypertension to hypertension: does TROPHY win the prize?. Am J Hypertens. 2006;19:1097
  4. Julius S, Nesbitt S, Egan B, Kaciroti N, Schork MA, Grozinski M, et al. Trial of preventing hypertension: design and 2-year progress report. Hypertension. 2004;44:146–151
  5. Chobanian AV, Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (The JNC 7 Report). JAMA. 2003;289:2560–2572
  6. Robinson SC, Brucer M. Range of normal blood pressure: a statistical and clinical study of 11,383 persons. Arch Intern Med. 1939;64:409–444
  7. The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC VI). Bethesda, Maryland: National Heart, Lung, and Blood Institute; 1997;(NIH publication 98-4080)

 AstraZeneca provided financial support for the TROPHY study and markets candesartan.

 Clinical trials gov no. NCT00227318.

 Conflict of interest: none.

PII: S1933-1711(07)00165-9

doi: 10.1016/j.jash.2007.07.005

Journal of the American Society of Hypertension
Volume 2, Issue 1 , Pages 39-43 , January 2008

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