Journal of the American Society of Hypertension
Volume 1, Issue 3 , Pages 185-188 , May 2007

Cardiovascular diseases, aging, and the gender gap in human longevity

  • Abraham Aviv, MD

      Affiliations

    • Dr. Aviv’s aging research is supported by the National Institutes of Health grants R01HL070137, R01AG20132, and R01AG021593 and by grants from The Healthcare Foundation of New Jersey.
    • Corresponding Author InformationCorresponding author: Abraham Aviv, MD, The Center of Human Development and Aging, Room F-464, MSB, The New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, New Jersey 07103. Tel: 973-972-5280; fax: 973-972-5576.

Received 14 December 2006 ,Accepted 11 February 2007.

References 

  1. World Population Data Sheet. Washington, DC: Population Reference Bureau; 2002;
  2. Bonita R, Howe AL. Older women in an aging world: achieving health across the life course. World Health Stat Q. 1996;49:134–141
  3. Moore KL, Persaud TVN. The beginning of human development. In: The developing human: clinically oriented embryology. Philadelphia, PA: Saunders; 1998;p. 14–39
  4. Karmarow E, Lentzner H, Rooks R, Weeks J, Saydah Sl. Health and aging chartbook. Health, United States. Hyattsville, MD: National Center for Health Statistics; 1999;
  5. Newman AB, Brach JS. Gender gap in longevity and disability in older persons. Epidemiol Rev. 2001;2:343–350
  6. Bernhard D, Moser C, Backovic A, Wick G. Cigarette smoke: an aging accelerator?. Exp Gerontol. 2007;42:160–165
  7. Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell. 2005;120:483–495
  8. Finch C, Crimmins EM. Inflammatory exposure and historical changes in human life-spans. Science. 2004;305:1736–1739
  9. Yager JD, Davidson NE. Estrogen carcinogenesis in breast cancer. N Engl J Med. 2006;354:270–282
  10. Mooradian AD. Antioxidant properties of steroids. J Steroid Biochem Mol Biol. 1993;45:509–511
  11. Reckelhoff JF. Cardiovascular disease, estrogen deficiency, and inflammatory cytokines. Hypertension. 2006;48:372–373
  12. Massafra C, Gioia D, DeFelice C, et al. Effects of estrogens and androgens on erythrocyte antioxidant superoxide dismutase, catalase and glutathione peroxidase activities during the menstrual cycle. J Endocrinol. 2000;167:447–452
  13. Sack MN, Rader DJ, Cannon RO. Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women. Lancet. 1994;343:269–270
  14. Forte P, Kneale BJ, Milne E, et al. Evidence for a difference in nitric oxide biosynthesis between healthy women and men. Hypertension. 1998;32:730–734
  15. Villar IC, Francis S, Webb A, Hobbs AJ, Ahluwalia A. Novel aspects of endothelium: dependent regulation of vascular tone. Kidney Int. 2006;70:840–853
  16. Koh KK, Yoon B-K. Controversies regarding hormone therapy: insights from inflammation and hemostasis. Cardiovasc Res. 2006;70:22–30
  17. Pfeilschifter J, Koditz R, Pfohl M, Schatz H. Changes in proinflammatory cytokine activity after menopause. Endocr Rev. 2002;23:90–119
  18. Malkin CJ, Pugh PJ, Jones RD, Jones TH, Channer SK. Testosterone as a protective factor against atherosclerosis: immunomodulation and influence upon plaque development and stability. J Endocrinol. 2003;178:373–380
  19. Brown CJ, Robinson WP. The causes and consequences of random and non-random X chromosome inactivation in humans. Clin Genet. 2004;58:353–363
  20. Carrel L, Willard HF. X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature. 2005;434:400–404
  21. Gale RE, Fielding AK, Harrison CN, Linch DC. Acquired skewing of X-chromosome inactivation patterns in myeloid cells of the elderly suggests stochastic clonal loss with age. Br J Haematol. 1997;98:512–519
  22. Sandovici I, Naumova AK, Leppert M, Linares Y, Sapienza C. A longitudinal study of X-inactivation ratio in human females. Hum Genet. 2004;115:387–392
  23. Christensen K, Orstavik KH, Vaupel JW. The X chromosome and the female survival advantage: an example of the intersection between genetics, epidemiology and demography. Ann N Y Acad Sci. 2001;954:175–183
  24. Ito K, Hirao A, Arai F, et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med. 2006;12:446–451
  25. Medawar DE. An unresolved problem of biology. London, England: Lewis; 1952;
  26. Williams GC. Pleiotropy, natural selection, and the evolution of senescence. Evolution. 1957;11:398–411
  27. Hamilton WD. The moulding of senescence by natural selection. J Theor Biol. 1966;12:12–45
  28. Kirkwood TB. Evolution of ageing. Nature. 1977;270:301–304
  29. Hawkes K, O’Connell JF, Jones NG, Alvarez H, Charvov EL. Grandmothering, menopause, and the evolution of life histories. Proc Natl Acad Sci U S A. 1998;95:1336–1339
  30. Lahdenpera M, Lummaa V, Helle S, Tremblay M, Russel AF. Fitness benefits of prolonged post-reproductive lifespan in women. Nature. 2004;428:178–181
  31. Austad SN. Menopause: an evolutionary perspective. Exp Gerontol. 1994;29:255–263
  32. Reznick D, Bryant M, Holmes D. The evolution of senescence and post-reproductive life span in guppies (Poecilia reticulata). PLoS Biol. 2007;4:e7
  33. Ossewaarde ME, Bots ML, Verbeek AL, et al. Age at menopause, cause-specific mortality and total life expectancy. Epidemiology. 2005;16:556–562
  34. Helle S, Lummaa V, Jokela J. Are reproductive and somatic senescence coupled in humans? (Late, but not early, reproduction correlated with longevity in historical Sami women). Proc Biol Sci. 2005;272:29–37
  35. Perls TT, Alpert L, Fretts RC. Middle-aged mothers live longer. Nature. 1997;389:133
  36. van der Schouw YT, van der Graaf Y, Steyerberg EW, Eijkemans MJC, Banga JD. Age at menopause as a risk for cardiovascular mortality. Lancet. 1996;347:714–718
  37. Jacobsen BK, Nilssen S, Heuch I, Kvale G. Does age at natural menopause affect mortality from ischemic heart disease?. J Clin Epidemiol. 1997;50:475–479
  38. Westendorp RG, Kirkwood TB. Human longevity at the cost of reproductive success. Nature. 1998;396:743–746
  39. Gavrilova NS, Gavrilov LA, Semyonova VG, Evdokushkina GN. Does exceptional human longevity come with a high cost of infertility? (Testing the evolutionary theories of aging). Ann N Y Acad Sci. 2004;1019:513–517
  40. Barker DJP, Winter PD, Osmond C, Margetts B, Simmonds SJ. Weight in infancy and death from ischaemic heart disease. Lancet. 1989;3:577–580
  41. Frankel S, Elwood P, Sweetnam P, Yarnell J, Smith GD. Birthweight, body-mass index in middle age, and incident coronary heart disease. Lancet. 1996;348:1478–1480
  42. Frankel S, Elwood P, Sweetnam P, Yarnell J, Smith GD. Birthweight, adult risk factors and incident coronary heart disease: the Caerphilly study. Public Health. 1996;110:139–143
  43. Leon DA, Lithell HO, Vagero D, et al. Reduced fetal growth rate and increased risk of death from ischaemic heart disease: cohort study of 15,000 Swedish men and women born 1915-1929. BMJ. 1998;317:241–245
  44. Pell JP, Smith GC, Dominiczak A, et al. Family history of premature death from ischaemic heart disease is associated with an increased risk of delivering a low birth weight baby. Heart. 2003;89:1249–1250
  45. Pell JP, Smith GC, Walsh D. Pregnancy complications and subsequent maternal cerebrovascular events: a retrospective cohort study of 119,668 births. Am J Epidemiol. 2004;159:336–342
  46. Smith GD, Whitley E, Gissler M, Hemminki E. Birth dimensions of offspring, premature birth, and mortality of mothers. Lancet. 2002;356:2066–2067

 Conflict of interest: none.

PII: S1933-1711(07)00056-3

doi: 10.1016/j.jash.2007.02.002

Journal of the American Society of Hypertension
Volume 1, Issue 3 , Pages 185-188 , May 2007