Journal of the American Society of Hypertension
Volume 1, Issue 2 , Pages 150-160, March 2007

Inhibitory effects of PPAR-γ on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats

  • Augusto C. Montezano, PhD

      Affiliations

    • Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    • ,
  • Farhad Amiri, PhD

      Affiliations

    • Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada
    • ,
  • Rita C. Tostes, PhD

      Affiliations

    • Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    • ,
  • Rhian M. Touyz, MD, PhD

      Affiliations

    • Kidney Research Centre, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Ernesto L. Schiffrin, MD, PhD, FRCPC

      Affiliations

    • Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada
    • Corresponding Author InformationCorresponding author: Ernesto L. Schiffrin, MD, PhD, FRCPC, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, 3755 Côte Ste-Catherine Road, B-127, Montreal, Quebec, Canada H3T 1E2. Tel: 514-340-7538; fax: 514-340-7539.

Received 1 December 2006; accepted 18 January 2007.

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 This work was supported by Grants 37917 (to Dr. Schiffrin) and 44018 (to Dr. Touyz), and by a group grant to the Multidisciplinary Research Group on Hypertension, all from the Canadian Institutes of Health Research (CIHR). Drs. Touyz and Schiffrin are recipients of Canada Research Chairs. Drs. Montezano and Tostes were supported by CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior), CNPq (Conselho Nacional De Desenvolvimento Científico e Tecnológico) and FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo; 01/13642-3), Brazil.Conflict of interest: none.

PII: S1933-1711(07)00017-4

doi:10.1016/j.jash.2007.01.005

Journal of the American Society of Hypertension
Volume 1, Issue 2 , Pages 150-160, March 2007

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