Journal of the American Society of Hypertension
Volume 1, Issue 1 , Pages 45-55 , January 2007

Role of nitric oxide deficiency and its detection as a risk factor in pre-hypertension

  • Masood Gilani, MD

      Affiliations

    • Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    • Current address: Bay Pines VA Hospital, St. Petersburg, Florida, USA
  • ,
  • Daniel R. Kaiser, PhD

      Affiliations

    • Research Division, Saint Paul Heart Clinic, St. Paul, Minnesota, USA
    • Current address: Medtronic, Minneapolis, Minneapolis, USA
  • ,
  • Christopher W. Bratteli, MD

      Affiliations

    • Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    • Current address: University of Texas Southwestern Medical Center, Dallas, Texas, USA
  • ,
  • Cheryl Alinder, LPN

      Affiliations

    • Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
  • ,
  • Scott Rajala, BS

      Affiliations

    • Research Division, Saint Paul Heart Clinic, St. Paul, Minnesota, USA
  • ,
  • Alan J. Bank, MD

      Affiliations

    • Research Division, Saint Paul Heart Clinic, St. Paul, Minnesota, USA
  • ,
  • Jay N. Cohn, MD

      Affiliations

    • Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    • Dr. Jay N. Cohn is a founder and stockholder of Hypertension Diagnostics, Inc., the manufacturer of the CR2000 CV Profilor that was provided for use in this study.
    • Corresponding Author InformationCorresponding author: Jay N. Cohn, MD, Cardiovascular Division, Mayo Mail Code 508, University of Minnesota Medical School, 420 Delaware Street, SE, Minneapolis, Minnesota 55455. Tel: 612-625-5646; fax: 612-624-2174.

Received 9 November 2006 ,Accepted 10 November 2006.

References 

  1. Chobanian AV, Bakris GL, Black HR, et al. National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure National High Blood Pressure Education Program Coordinating Committee The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289:2560–2572
  2. Cohn JN, Franciosa JA, Francis GS, et al. Effect of short-term infusion of sodium nitroprusside on mortality rate in acute myocardial infarction complicated by left ventricular failure. N Engl J Med. 1982;306:1129–1135
  3. Perticone F, Ceravolo R, Pujia A, et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation. 2001;104:191–196
  4. Gokce N, Keaney JF, Hunter LM, et al. Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. J Am Coll Cardiol. 2003;41:1769–1775
  5. Panza JA, Quyyumi AA, Brush JE, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med. 1990;323:22–27
  6. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular disease: the role of oxidant stress. Circ Res. 2000;87:840–844
  7. Vasan RS, Larson MG, Leip EP, et al. Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med. 2001;345:1291–1297
  8. Celermajer D, Sorensen KE, Gooch VM, et al. Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992;340:1111–1115
  9. Joannides R, Haefeli WE, Linder L, et al. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation. 1995;91:1314–1319
  10. Corretti MC, Anderson TJ, Benjamin EJ, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002;39:257–265
  11. Taddei S, Virdis A, Mattei P, et al. Vasodilation to acetylcholine in primary and secondary forms of human hypertension. Hypertension. 1993;21:929–933
  12. Haynes WG, Noon JP, Walker BR, Webb DJ. Inhibition of nitric oxide synthesis increases blood pressure in healthy humans. J Hypertens. 1993;11:1375–1380
  13. McVeigh GE, Allen PB, Morgan DR, et al. Nitric oxide modulation of blood vessel tone identified by arterial waveform analysis. Clin Sci. 2001;100:387–393
  14. Sander M, Chavoshan B, Victor RG. A large blood pressure-raising effect of nitric oxide synthase inhibition in humans. Hypertension. 1999;33:937–942
  15. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999;340:115–126
  16. Wever RM, Luscher TF, Cosentino F, Rabelink TJ. Atherosclerosis and the two faces of endothelial nitric oxide synthase. Circulation. 1998;97:108–112
  17. Vane JK, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med. 1990;323:27–36
  18. Finkelstein SM, Cohn JN. First- and third-order models for determining arterial compliance. J Hypertens. 1992;10;:S11–S14
  19. Cohn JN, Finkelstein S, McVeigh G, et al. Non-invasive pulse wave analysis for the detection of arterial vascular disease. Hypertension. 1995;26:503–508
  20. Langewouters GJ, Wesseling KH, Goedhard WJA. The static elastic properties of 45 human thoracic and 20 abdominal aortas in vitro and the parameters of a new model. J Biomech. 1984;17:425–435
  21. Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 1989;2:997–1000
  22. Cohn JN, Hoke L, Whitwam W, et al. Screening for early detection of cardiovascular disease in asymptomatic individuals. Am Heart J. 2003;146:679–685
  23. Vaughn MW, Kuo L, Liao JC. Effective diffusion distance of nitric oxide in the microcirculation. Am J Physiol. 1998;274:H1705–H1714
  24. Bank AJ, Wang H, Holte JE, Mullen K, Shammas R, Kubo SH. Contribution of collagen, elastin, and smooth muscle to in vivo human brachial artery wall stress and elastic modules. Circulation. 1996;94:3263–3270
  25. Benetos A, Adamopoulos C, Bureau J-M, et al. Determinants of accelerated progression of arterial stiffness in normotensive subjects and in treated hypertensive subjects over a 6-year period. Circulation. 2002;105:1202–1207
  26. Joannides R, Richard V, Haefeli WE, Linder L, Luscher TF, Thuillez C. Role of basal and stimulated release of nitric oxide in the regulation of radial artery caliber in humans. Hypertension. 1995;26:327–331
  27. Lefroy DC, Crake T, Uren NG, Davies GJ, Maseri A. Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans. Circulation. 1993;88:43–54
  28. Freis ED. Hemodynamics of hypertension. Physiol Rev. 1960;40:27–54
  29. McVeigh GE, LeMay L, Morgan D, Cohn JN. Effects of long-term cigarette smoking on endothelium-dependent responses in humans. Am J Cardiol. 1996;78:668–672
  30. Celermajer DS, Adams MR, Clarkson P, et al. Passive smoking and impaired endothelium-dependent arterial dilation in healthy young adults. N Engl J Med. 1996;334:150–154
  31. Vogel RA, Corretti MC, Plotnick GD. Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol. 1997;79:350–354
  32. Bramwell JC, Hill AV. The velocity of the pulse wave in man. Proc Royal Soc London. 1922;93B:298–306
  33. Bank AJ, Kaiser DR, Rajala S, Cheng A. In vivo human brachial artery elastic mechanics: effects of smooth muscle relaxation. Circulation. 1999;100:41–47
  34. O’Rourke MF, Pauca AL. Augmentation of the aortic and central arterial pressure waveform. Blood Press Monit. 2004;9:179–185
  35. Hope SA, Tay DB, Meredith IT, Cameron JD. Comparison of generalized and gender-specific transfer functions for the derivation of aortic waveforms. Am J Physiol Heart Circ Physiol. 2002;283:H1150–H1156
  36. Millasseau SC, Patel SJ, Redwood SR, Ritter JM, Chowienczyk PJ. Pressure wave reflection assessed from the peripheral pulse: is a transfer function necessary?. Hypertension. 2003;41:1016–1020
  37. McVeigh G, Brennan G, Hayes R, Cohn JN, Finkelstein S, Johnston D. Vascular abnormalities in non-insulin-dependent diabetes mellitus identified by arterial waveform analysis. Am J Med. 1993;95:424–430
  38. McVeigh GE, Burns DE, Finkelstein SM, et al. Reduced vascular compliance as a marker for essential hypertension. Am J Hypertens. 1991;4:245–251
  39. McVeigh GE, Morgan DJ, Finkelstein SM, LeMay LA, Cohn JN. Vascular abnormalities associated with long-term cigarette smoking identified by arterial waveform analysis. Am J Med. 1997;102:227–231
  40. McVeigh GE, Bratteli CW, Morgan DJ, et al. Age-related abnormalities in arterial compliance identified by pressure pulse contour analysis. Hypertension. 1999;33:1392–1398

 Conflict of interest: none.

PII: S1933-1711(06)00005-2

doi: 10.1016/j.jash.2006.11.002

Journal of the American Society of Hypertension
Volume 1, Issue 1 , Pages 45-55 , January 2007